The story of CellTolerance®
The CellTolerance® program is grounded in more than a decade of clinical research demonstrating the power of live cell response visualisation of barrier function. Some key milestones include:
Initial patient enrollment and first publication1
Expansion of clinical research and second publication2
Clinical research presented at UEGW 2022
More clinical research presented at DDW 2023 and UEGW 2023
First 500 procedures completed globally
More clinical research presented at DDW 2024
First 1,000 procedures completed globally
Global launch of multi-disciplinary CellTolerance® program
Live cell-response visualisation.
CellTolerance® is powered by Cellvizio®, the real-time in vivo cellular imaging platform.
Cellvizio offers real-time, high-magnification visualization of cellular structures and functions, and this breakthrough technology empowers physicians to make better informed decisions across a wide range of medical specialties.
Cellvizio has been the subject of 1,100+ peer-reviewed publications and is utilized in hundreds of institutions around the world.
Backed by Clinical Evidence
1. Fritscher-Ravens A, Pflaum T, Mösinger M, Ruchay Z, Röcken C, Milla PJ, Das M, Böner M, Wedel T, Schuppan D. Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E. Gastroenterology. 2019 Jul;157(1):109-118.e5. doi: 10.1053/j.gastro.2019.03.046. Epub 2019 May 15. PMID: 31100380.
2. Fritscher-Ravens, Annette & Ruchay, Zino & Pflaum, Theresa & Moesinger, Marie & Schuppan, Detlef. (2020). 623 EXCLUSION OF ATYPICAL FOOD ALLERGENS DETECTED BY CONFOCAL ENDOMICROSCOPY IS SUPERIOR TO A LOW FODMAP DIET IN PATIENTS WITH FOOD-SENSITIVE IBS. Gastroenterology. 158. S-135. 10.1016/S0016-5085(20)31016-7.
3. Kiesslich, Ralf & Adib-Tezer, Hanan & Teubner, Daniel & Frieling, Thomas & Bayerl, Christiane & Wenda, Nina & Gosepath, Jan. (2021). ID: 3526039 FOOD ALLERGY SENSITIVITY TEST (FAST) WITH ENDOMICROSCOPY OF THE DUODENUM ENABLES TAILORED EXCLUSION DIET IN PATIENTS WITH IRRITABLE BOWEL SYNDROME. Gastrointestinal Endoscopy. 93. AB207. 10.1016/j.gie.2021.03.995.
4. M. Bittel, S. Weyrauch, M.-L. Groh, J. Langhorst (2024, October). TARGETING CONFOCAL LASER ENDOMICROSCOPY-IDENTIFIED GUT BARRIERDYSFUNCTION IN IRRITABLE BOWEL SYNDROME VIA MULTIMODAL INTEGRATIVE THERAPY IMPROVES BARRIER INTEGRITY AND SYMPTOM RELIEF –INSIGHTS FROM AN EXPLORATORY, PROSPECTIVE OBSERVATIONAL CLINICAL TRAIL. UEG Week 2024, Vienna, Austria.https://programme.ueg.eu/week2024/#/details/presentations/1712
5. Frieling T, Gjini B, Melchior I, Euler P, Kreysel C, Kalde S, Krummen B, Kiesslich R, Hemmerlein B. Gastrointestinal adverse reaction to food (GARF) and endoscopic confocal laser endomicroscopy (eCLE). Z Gastroenterol. 2024 Aug;62(8):1201-1206. English. doi: 10.1055/a-2258-8509. Epub 2024 May 15. PMID: 38749460.
6. Frieling T, Gjini B, Melchior I, Euler P, Kreysel C, Kalde S, Krummen B, Kiesslich R, Hemmerlein B. Endoscopic laser endomicroscopy and "leaky gut" in patients with functional gastrointestinal symptoms and food intolerance. Z Gastroenterol. 2023 Nov;61(11):1465-1471. English. doi: 10.1055/a-1959-3200. Epub 2022 Nov 23. PMID: 36417920.
7. Blomsten, Amanda & Gils, Tom & Algera, Joost & Josefsson, Axel & Hreinsson, Johann & Hedenström, Per & Störsrud, Stine & Tornblom, Hans & Simren, Magnus. (2024). Tu1682 FOOD-INDUCED INTESTINAL MUCOSAL REACTIONS IN IRRITABLE BOWEL SYNDROME DETECTED WITH CONFOCAL LASER ENDOMICROSCOPY. Gastroenterology. 166. S-1377. 10.1016/S0016-5085(24)03619-9.
8. Gjini B, Melchior I, Euler P, Kreysel C, Kalde S, Krummen B, Kiesslich R, Hemmerlein B, Frieling T. Food intolerance in patients with functional abdominal pain: Evaluation through endoscopic confocal laser endomicroscopy. Endosc Int Open. 2023 Jan 13;11(1):E67-E71. Doi: 10.1055/a-1978-6753. PMID: 36644536; PMCID: PMC9839425.
9. Balsiger, L.M., van Gils, T., Hatem, Y., Blomsten, A., Raymenants, K., Van de Bruaene, C., Juvyns, L., Hreinsson, J.P., Vanuytsel, T., Törnblom, H., Sina,C., Simren, M. and Tack, J. (2025), Intra- and Interobserver Variability of Acute Food–Induced Reactions During Confocal Laser Endomicroscopy:An International Multicenter Validation Study. Neurogastroenterology & Motility e70031. https://doi.org/10.1111/nmo.70031
10. Huang, Clifton et al., CONFOCAL LASER ENDOMICROSCOPY WITH FOOD ALLERGY SENSITIVITY TESTING TO DETECT ATYPICAL FOOD ALLERGIES INPEDIATRIC PATIENTS WITH CHRONIC ABDOMINAL PAIN AND IRRITABLE BOWEL SYNDROME, Gastrointestinal Endoscopy, Volume 99, Issue 6,AB1089 - AB1090, June 2024. https://www.giejournal.org/article/S0016-5107(24)02859-1/abstract
11. Kiesslich, Ralf & Adib-Tezer, Hanan & Teubner, Daniel & Frieling, Thomas & Mudter, Jonas & Bayerl, Christiane & Wenda, Nina & Gosepath, Jan. (2020).Su1344 ENDOMICROSCOPIC DETECTION OF ATYPICAL FOOD ALLERGY IN PATIENTS WITH IRRITABLE BOWEL SYNDROME – A NEW DIAGNOSTIC ERA?.Gastroenterology. 158. S-558. 10.1016/S0016-5085(20)32099-0.
12. Fritscher-Ravens A, Schuppan D, Ellrichmann M, Schoch S, Röcken C, Brasch J, Bethge J, Böner M, Klose J, Milla PJ. Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome. Gastroenterology. 2014 Nov;147(5):1012-20.e4. doi:
10.1053/j.gastro.2014.07.046. Epub 2014 Jul 30. PMID: 25083606.
13. Lukas Michaja Balsiger, Jolien Schol, Karlien Raymenants, Karen Routhiaux, Justine Luca, Joran Tóth, Tim Vanuytsel, Jan Tack (2022, October). CONFOCAL LASER ENDOMICROSCOPY FOOD ALLERGY TESTING IN FUNCTIONAL DYSPEPSIA AND IRRITABLE BOWEL SYNDROME. UEG Week 2022,
Vienna, Austria.
https://ueg.eu/library/confocal-laser-endomicroscopy-food-allergy-testing-in-functional-dyspepsia-and-irritable-bowel-syndrome/c2d4a046-
9363-11ed-82e0-0242ac140004
14.Frieling T, Gjini B, Melchior I, Hemmerlein B, Kiesslich R, Kuhlbusch-Zicklam R. Eosinophilic esophagitis and duodenal food challenge - evaluation through endoscopic confocal laser endomicroscopy. Z Gastroenterol. 2024 Mar;62(3):399-403. English. doi: 10.1055/a-2057-9125. Epub 2023 Oct 24. PMID: 37875128.
15. Schol, Jolien & Balsiger, Lukas & Tóth, Joran & Wauters, Lucas & Houte, Karen & Huang, I-Hsuan & Vanuytsel, Tim & Carbone, Florencia & Tack, Jan. (2022). Tu1346: ROLE OF ATYPICAL FOOD ALLERGIES IN FUNCTIONAL DYSPEPSIA: EVALUATION BY SIX-FOOD ELIMINATION DIET AND CONFOCAL LASER ENDOMICROSCOPY FOOD ALLERGY TESTING. Gastroenterology. 162. S-926. 10.1016/S0016-5085(22)62199-1.
16. Balsiger LM, Rusticeanu M, Langhorst J, Sina C, Benamouzig R, Huang C, Tack J, Kiesslich R. Review: Food-induced mucosal alterations visualized
using endomicroscopy. Neurogastroenterol Motil. 2024 Sep 24:e14930. doi: 10.1111/nmo.14930. Epub ahead of print. PMID: 39314095.